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Thats part of the reason why I dont think weight loss itself is the surrogate

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Corroborating a functional role of GIPR, GLP-1GIPLani decreased body weight and food intake with increased efficacy compared with GLP-1Lani, but with equal efficacy to co-therapy of GLP-1Lani and a long-acting GIPR agonist (acyl-GIP) (Fig