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Besides decreased body weight and glycemia, a decrease in systolic blood pressure by 2.22 mmHg was noted across 33 clinical trials [74], thus decreasing the incidence of hypertension, one of the main risk factors involved in the development of diabetic nephropathy [75]

Similarly, genes involved in cell cycle regulation and ECM organization, including those in the collagen biosynthesis and modifying enzymes pathway (ADAM metallopeptidase domain 12 ( Adam12) , laminin subunit beta 3 ( Lamb3 ), collagen type VI alpha 3 ( Col6a3 ), neurocan ( Ncan ) and integrin alpha 6 ( Itga6 )) also exhibited reduced expression

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From a cardiovascular perspective, the glucagon components contribution to increased energy expenditure and fat oxidation translates to greater reductions in the visceral fat deposits most strongly associated with cardiovascular disease

doi: 10.1016/j.bbamcr.2016.09.012 53 QinJGuoSYangJQaziIHPanBLvTet al