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The two major limitations of this trial are that the treatment duration was only for 28 d and the subjects were under generally excellent metabolic control
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In line with the RSL3 data, cholesterol rendered HT1080 cells more resistant to RSL3, cysteine starvation, erastin treatment as well as when GPX4 is deleted by CRISPR mediated knockout, with a comparable potency to Fer-1 (ferrostatin-1) (Fig
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