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The Journal of Clinical Endocrinology & Metabolism, 91 (3), 799-805.

Nevertheless, early observational studies and subgroup analyses suggest that metabolic improvements may still occur regardless of baseline BMI

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For weight management, NICE recommends liraglutide 3mg (Saxenda) or semaglutide 2.4mg (Wegovy) for adults with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities) alongside a reduced-calorie diet and increased physical activity