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The SS-31 peptide and other mitochondrial-targeted peptides are being studied for their cardiovascular protective properties

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(1) FSP1/AIFM2: FSP1 was originally classified as a caspase-independent apoptosis-inducing protein, on the basis of its sequence similarity to apoptosis-inducing factor 1 (AIFM1), and was annotated as a flavoprotein with NAD(P)H oxidase activity 38

Shih et al

Multiple large-scale trials, including the STEP program (Semaglutide) and the SELECT trial (Tirzepatide), demonstrated 1522% body weight reduction over 68 weeks compared to 23% with placebo

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