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However, their overexpression on tumor cells results in over-activation of certain intercellular signaling pathways of proliferation, migration, and invasion of tumor cells

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Depending on the type of cancer and stage, this can include hypoxia-related ROS functions and signalling pathways such as PI3K/AKT or MAPK/ERK pathways, among others, to promote proliferation, migration, or angiogenesis

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