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2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

10 These adverse events are likely to affect patient tolerability and compliance

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Fatigue or irritability

What it boils down to is the fact that IGF-1 will stimulate certain pathways which will stimulate pro-growth and survival but at the same time they will lead to aging due to a variety of effects

It blurs or perhaps obliterates the line between treatment and doping