Additionally, local NPY/AgRP neurons can secrete the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which suppresses the activity of related POMC neurons, further enhancing appetite [40]
In any case, systemic action would be needed to fully mimic drug-like effects (e.g., lowering blood glucose via insulin or affecting fat storage)
Smaller meals and slower digestion Because digestion slows, a large, high-fat meal can sit heavier and make nausea or reflux more likely
& Christophe, E
Int J Obes (2007) 31(12):177785
Pregnancy, placental biology, and implantation Endogenous HCG and its hyperglycosylated variants regulate implantation, trophoblast invasion, angiogenesis, and placental development, so they are widely studied in preeclampsia, recurrent pregnancy loss, and gestational trophoblastic disease