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After that, only non-manufactured, custom dosing can be compounded

doi: 10.3390/ijms23020583 [DOI] [PMC free article] [PubMed] [Google Scholar] 6.Wang J, Wu D, Guo H, Li M

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The body makes three main estrogens: Estrone (E1) Estradiol (E2) Estriol (E3) Estrone (E1) is the main type of estrogen present in the body after menopause, made primarily in adipose tissue

Although preliminary findings suggest potential benefit in reducing autoantibodies or improving metabolic markers, these results are primarily drawn from small-scale or uncontrolled studies and lack replication in high-quality RCTs.In summary, while the biological rationale for supplement use in HT is compelling, robust clinical evidence remains limited