At the same time, the glycine group lost 27 percent less lean mass and had better preserved quadriceps muscle mass by 4 percent compared to controls
Additionally, uncontrolled hyperglycemia itself causes dry mouth through osmotic diuresis, though semaglutide's glucose-lowering effects should theoretically improve rather than worsen this symptom in patients with diabetes
More than 50 percent of trial participants are losing 15 percent of their body weight. (4) 2
Research from the STEP 1 exploratory analysis using DEXA scans revealed that semaglutide-induced weight loss comprises approximately 60 percent fat mass and 40 percent lean mass
However, individual reactions can vary, so some people may find that they can tolerate tirzepatide better than semaglutide
Your body cannot process double the GLP-1 receptor activation safely, and the side effects will be disproportionately worse than any benefit from the extra semaglutide