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The textbooks specifically advise that all oral pigmented macules of recent onset, large size, irregular pigmentation, unknown duration or recent enlargement should be biopsied to exclude early melanoma

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Preexisting subclinical gallbladder disease is characterized by visualizing stones or sludge in the gallbladder, which typically appears as low-level, mobile echoes with no acoustic shadowing, often layering in the dependent portion of the gallbladder and moving with positional changes

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