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The downstream effects on adipose-tissue gene expression, methylation status, and NAD + pool dynamics are interpreted in the published literature as the basis for the metabolic phenotype observed in mouse models

Notably, nicotinamide mononucleotide (NMN), a direct NAD + precursor, was markedly elevated in HPV-positive HNSCC cells 43

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Glutamine uptake by Slc7a8 (also known as L-type amino acid transporter 2- LAT2) promotes glycolysis, after mTOR activation, and chemoresistance of pancreatic tumor cells in a mouse model [172]