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13b, Supplementary Table 9), indicating that the interactions between the C-terminal tyrosine and RAMP3 can compensate, in this peptide context, the reduced CTR ECD affinity derived from the P37Y substitution

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The upper result, plus the evidence that the ratio of IL18R1/CXCR3 is six fold more in the ovary than in the tumor, supports that IL18R1 is surplus and CXCL10 can directly bind to IL18R1 (Supplementary Fig