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The RNA helicase DDX3 promotes IFNB transcription via enhancing IRF-3/p300 holocomplex binding to the IFNB promoter

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The interaction of gliadin and its immunomodulatory fragments with chemokine CXC receptor 3 on IECs induces zonulin release and downstream disassembly of TJs which has been reported previously among coeliac patients (Lammers et al