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Conversely, studies have shown that both patients and healthcare professionals are reluctant to initiate GLP-1RAs [11, 12], despite the guideline recommendations and the health benefits of these therapies, particularly for patients in need of weight loss and those with low estimated glomerular filtration rate [1]

Those aren't theoretical differences

Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination

Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells

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These medications may suppress appetite and reduce cravings, but they don't automatically rewire the brain's response to stress, anxiety, or other emotional triggers that lead to comfort eating