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Telomere shortening is a key hallmark of cellular senescence (a state where cells permanently stop dividing but dont die)

Adams, J

In some cases, a staggered approach may be considered: Cortisone first If a joint is severely inflamed, a cortisone injection may be given to quickly reduce swelling and pain PRP later After a few weeks (once cortisone effects wear off), PRP can be injected to promote long-term healing

[DOI] [PubMed] [Google Scholar] 16.Pogatzki EM, Gebhart GF, Brennan TJ

CoA-LOT: BNBN20251114/CA

Phase 1: loading (weeks 1 to 8) The loading phase establishes tissue levels and initiates regenerative processes