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Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA)

IGF-1 LR3 is a full agonist at the type 1 IGF receptor (IGF-1R), a transmembrane receptor tyrosine kinase

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Since complex biological pathways are involved in fibrosis progression, multi-disciplinary therapeutic approaches should be required to effectively deliver treatment effects on fibrosis

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