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Rivero, J.L.L., et al

When a compound changes gene expression, it alters which proteins a cell produces potentially shifting the cell's behaviour toward repair, growth, or protection

McCutcheon RA, Abi-Dargham A, Howes OD

Bibcode:2004ToxAP.198..209C

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The reason most peptide guides get this wrong is that they apply pharmacokinetic models designed for small-molecule drugs (where receptor binding and plasma concentration are tightly coupled) to peptides with entirely different mechanisms