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FIGURE 3 3.1 Risk of bias assessment Risk of bias was evaluated using the Cochrane RoB 2 tool for the four controlled trials included in the quantitative synthesis

3cg are the simple linear regression lines (Extended Data Table 2)

A total of 150 patients were randomized 1:1 to L-carnitine (2 g/day) or placebo for 24 weeks

Each starts at a low dose that can be increased every four weeks as tolerated and needed

Top companies in the market include Novo Nordisk A/S, Eli Lilly and Company, Sanofi and AstraZeneca North America dominated the market in 2024, holding the largest revenue share of 68.4%

Vitamin B12, an essential water-soluble vitamin, plays a key role in red blood cell formation, nervous system function, and cellular energy metabolism