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GLP-1 medications produce significant weight loss in clinical trials, with average results ranging from 15 to 22 percent of body weight depending on the medication and dose

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This release of secondary messenger molecules such as IP3 might potentially stimulate the discharge of calcium ions (Ca2+) from the cell's internal stores, while DAG might activate protein kinase C (PKC)

The agency also did not provide an estimated cost of continuing to cover the drugs for weight loss

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