The medication is absorbed effectively in the gut and activates the GLP-1 receptor
However, growth hormone has also demonstrated effects in maintaining body composition
Tirzepatide: A dual GLP-1 and GIP receptor agonist that enhances insulin secretion, reduces hunger, and improves metabolic function, marketed under brand names like Mounjaro and Zepbound
However, retatrutide remains investigational and is not yet approved in the UK or United States, with regulatory submission still pending and approval not anticipated before 2027 at the earliest
The Journal of Clinical Endocrinology & Metabolism, 82(5), 14721479
Individuals carrying certain genetic variants associated with higher baseline metabolic dysfunction or altered blood pressure regulation may show different GLP-1 response profiles compared to other patients