It has a natural, high affinity for copper ions, forming the GHK-Cu complex that is found in human plasma, saliva, and urine
The mechanism of action of this enzyme is described in Figure 12.5
Experimental data indicate that GHK-Cu can influence collagen and glycosaminoglycan synthesis, modulate proteoglycan and chondroitin sulfate turnover, and recruit fibroblasts, immune cells, and endothelial cells to sites of tissue injury
While AOD-9604 increases fat oxidation from adipose stores, the total contribution to daily energy expenditure remains modest
Another concept is to measure B12 bound to the plasma protein transcobalamin (holoTC, active B12) before and after administration of three high physiological doses of B12 for two days
The serum is still fresh up to 6 months after opening (with the activeness slowly depleting over time)