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What the published record does establish clearly is the result: studies appear to have been cancelled or stopped without any published conclusions, leaving a compound with over three decades of preclinical research and almost no completed human trial data [10]

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Despite the promise of GLP-1 agonists in treating both diabetes and obesity, there are several practical considerations that patients and healthcare providers should take into account when considering these drugs for off-label use: Understand the Off-Label Nature of the Treatment: Patients who are prescribed GLP-1 agonists for weight loss should be made aware that this use is off-label, meaning that the FDA has not officially approved the drug for this purpose

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The mechanism is different from direct TrkB activation