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For the research context it is key for understanding why amylin analogs do not develop tolerance with chronic use (unlike many other anti-obesity molecules)

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Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus

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Furthermore, specific KOs s were found to be more abundant in each treatment group, uniquely, when compared to T1, particularly in T5 (68 KOs), where they were mainly encoding for proteins involved in the biosynthesis of cofactors ( AKR1A1 , ALDH , bioB , phoA , menB , pdxB ) and glycosaminoglycan degradation ( hya and HEXA_B )