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It is a recommendation to FDA, not a rule

The existence of this correlation is supported by preclinical studies in mouse xenograft models, which showed that the therapeutic inhibition of angiogenesis reduces tumor vascularization and causes hypoxia, and therefore may promote c-Met-mediated invasion of malignant cells [50]

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In the same year, Wang et al

The daily injection requirement deters some patients but provides steady levels without the peaks and troughs of weekly dosing

In a 2024 review of studies, researchers reported that elevated levels of vitamin B12 in the blood were associated with higher all-cause mortality in adults and older adults