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Given the confinement of trial evidence to patients with the established indications for use of GLP-1 agonists, howeverpatients either had a BMI of 27 or greater, type 2 diabetes mellitus, or boththe literature remains incomplete

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exendin-4 (purple, 1 g/kg body weight) or vehicle (black) injection on cumulative ad libitum food intake in 12- to 18-week-old male WT ( K ) and Bbs5 / ( L ) mice over 24 hours ( n = 8 per group)