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Description

The most common injection areas include the abdomen, thigh, and upper arm

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In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing

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doi: 10.1016/j.pcd.2026.01.003

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Orlistat has been studied for up to 2 years

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