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Some healthcare providers may choose to implement a stepwise dose reduction (for example, decreasing from 15 mg to 10 mg to 5 mg over several weeks) not because tapering is pharmacologically required, but to allow time for: Transitioning to alternative therapies Implementing lifestyle modifications Monitoring metabolic parameters Adjusting other medications Psychological preparation for treatment changes This approach represents clinical judgment rather than medical necessity

Indicaciones: Anticelultico

Two cohorts of male WT (TN, n = 4

For Lebers optic atrophy or smokers blindness, the usual dose starts at 1000mcg, given daily for 2 weeks, followed by twice weekly

Caruso I, Di Gioia L, Di Molfetta S, et al

J Biol Chem 265:1291612926 Richards EM, Rosenthal RE, Kristian T, Fiskum G (2006) Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity