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Importantly, our results directly demonstrate lipolysis and GCGR-mediated effects of G49 in ketogenesis and plasma FGF21 elevation, the latter likely derived from the liver in agreement with a recent study demonstrating glucagon-induced upregulation of Fgf21 mRNA translation associated with suppressed activity of the mechanistic target of rapamycin complex 1 55

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If the pre-filled syringe dropped on a hard surface, do not use it