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FIGURE 2 3 Redox dysregulation in disease states 3.1 GSH in peripheral immune cell infiltration Several studies indicate that neuroinflammatory changes associated with neurodegeneration compromise the BBB or its function by disrupting transport systems, facilitating the infiltration of immune cells, and influencing the BBBs role as a signaling interface

Although selective SIRT3 activators are currently confined to preclinical studies, accumulating evidence indicates that SIRT3 can de-lactylate both mitochondrial and nuclear substrates, highlighting a potential route to therapeutically erase pathological lactylation [328]

Therefore, a placebo effect cannot be ruled out

J., Laughlin-Tommaso, S

The decision to start a GLP-1 is individual, based on your own risks and benefits