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49 Furthermore, the constitutive expression of claudin-1 in gut epithelium in mice resulted in decreased claudin-7 expression and enhanced susceptibility to acute colitis

It was shown that higher D 2 activity in mouse adipose tissue enhanced oxygen consumption [37]

limit caffeine and alcohol, which have diuretic effects

But while the world is going to just continue to yell about the weight loss numbers, I want to discuss the fact that this drug seems to be about as close to a metabolic fix it all, unlike anything weve seen before

Your healthcare team can discuss whether switching to an alternative agent or trying a different class of diabetes medication (such as SGLT2 inhibitors or DPP-4 inhibitors) might be appropriate for your individual circumstances, in line with NICE guidance