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In Studies 2, 3, 5, 7, 8 and 9, all patients received instruction for a reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended to a minimum of 150 min/week) that began with the first dose of study medication or placebo and continued throughout the trial

The PRR identifies potential adverse drug reactions (ADRs) through disproportionate reporting rates, with thresholds of PRR 2, 3 cases, and 2 4 indicating significant associations 25

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For thousands of active customers, many of whom had orders in transit or were mid-protocol, the shutdown was sudden and absolute