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Malondialdehyde (MDA) levels in each group were determined using the Lipid Peroxidation MDA Assay Kit (Beyotime, China), according to the manufacturers instructions

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Consistently, clinical and preclinical OA studies indicated a cumulative oxidative burden in osteoarthritic chondrocytes 39,40

People with gastrointestinal diseases affecting nutrient absorption may require high doses of vitamin B12 supplements

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Although many patients experience no side effects, mild discomfort such as a headache or slight nausea may occasionally occur