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Cancer Res 59(18):46934701 Bliwise DL, Mercaldo ND, Avidan AY, Boeve BF, Greer SA, Kukull WA (2011) Sleep disturbance in dementia with Lewy bodies and Alzheimers disease: a multicenter analysis

Offermanns S, Hashimoto K, Watanabe M, Sun W, Kurihara H, Thompson RF, et al

In conjunction, these studies underscore that the inhibition of aspartate and asparagine metabolism, or their deprivation, might be a compelling therapeutic strategy against some tumors

Small uncontrolled studies cannot establish the same confidence as well-designed randomized trials

Whilst one meta-analysis of 24 RCTs found a decrease in the pro-inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6), 15 the other (based on 28 studies) found a decrease in interleukin-8 (IL-8) when pooling all data and a decrease in IL-6 in a subset of studies using a dose of 1200 mg NAC per day or less, but no difference in CRP

However, the improvement in hypoglycemia was not reported