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Water Retention: In some cases, IGF-1 DES (1,3) may cause mild water retention, particularly in the early stages of use

Notably, this comes as the FDA introduced a so-called Green List in September 2025: a mechanism aimed at preventing potentially unsafe active pharmaceutical ingredients (APIs) from unverified foreign sources, particularly those for GLP-1 drugs, from entering the U.S

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Wu and colleagues generated a compound KO/transgenic mouse model (GHRKO-HIT) to assess the importance of local IGF-I production for skeletal development (72)

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