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CONCLUSIONS: One year after withdrawal of once-weekly subcutaneous semaglutide 2.4 mg and lifestyle intervention, participants regained two-thirds of their prior weight loss, with similar changes in cardiometabolic variables

Rodent studies showed dose-dependent C-cell tumor formation, and while causality in humans is unproven, the risk-benefit ratio makes these absolute contraindications

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Proc Natl Acad Sci U S A 75(10):48064809 Wickham S, Regan N, West MB, Thai J, Cook PF, Terzyan SS, Li PK, Hanigan MH (2013) Inhibition of human gamma-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors

Agarwal, P., Singh, L., Anand, M