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impaired in type 2 Cagrilintide Long-acting amylin analogue (engineered copy) Binds to amylin and calcitonin receptors Half-life: ~7 days Once-weekly subcutaneous injection Designed specifically for chronic weight management How Cagrilintide works in the body Cagrilintide exerts its effects by binding to amylin receptors specifically the calcitonin receptor in combination with receptor activity-modifying proteins (RAMP1 and RAMP3)

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Lancet Diabetes Endocrinol 7(7):549559 Mok J et al (2023) Safety and efficacy of liraglutide, 3.0 mg, once daily vs placebo in patients with poor weight loss following metabolic surgery: the BARI-OPTIMISE randomized clinical trial

4 It also has a role in supporting T cell function

Novo Nordisk launched oral Wegovy back in January, and Eli Lilly's just-approved Foundayo pill begins shipping today

But, multiple patient deaths in the triplet group sparked safety fears