It's about predictability
While some patients report a slight change in their food noise or cravings within the first 24 to 48 hours, for most, it takes several doses to reach a therapeutic level in the bloodstream
Joseph AM, Adhihetty PJ, Buford TW, et al
If daily injections are given, 100% of the NPH dose should be replaced and then adjusted
Although energy metabolism status can also regulate intracellular ROS levels (e.g., glucose deprivation leads to a marked increase in cellular ROS) [53,54,55,56], our study demonstrated that supplementation with energy substrates such as sodium pyruvate in GGCT-knockdown cell models did not induce significant alterations in intracellular ROS levels
All statements about relative bioavailability are extrapolations from animal pharmacology and general peptide pharmacokinetic principles