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Notably, the repression of lipogenic gene and protein expression and the decreased serum triglyceride levels seen in Gclc L-KO mice were reversed in L-DKO mice (Fig

The disconnect between this promising science and clinical application is stark: not a single human trial exists for mental health applications, leaving patients and clinicians with compelling mechanisms but zero human efficacy or safety data

This presents issues in data generalisability to the wider population, which should be addressed in future by the use of more diverse cohorts

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Moxifloxacin is not substrate of the CYP450 system, nor does it affect such enzymes, minimizing its interaction with other drugs