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Randomized trials that isolated B12 tend to be small or combine the vitamin with other agents, making causal claims weak

Women between 40 and 60 years old face the highest risk

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Preclinical studies in obese animal models further indicate that AOD 9604 enhances lipolytic activity within adipose tissue, with preferential effects observed in metabolically dysregulated fat cells [2]

The body readily converts cyanocobalamin to active forms through normal metabolic pathways, so bioavailability differences between B12 forms are minimal in individuals with intact conversion capacity

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