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However, these findings also propose that tipping the balance in favor of GLP-1, either by GLP-1R agonist-based therapies or DPP-4 inhibitors, is a viable approach to help correct dyslipidemia in insulin-resistant/diabetic states

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Additional GLP-1 receptor agonist risks include pancreatitis (severe, persistent abdominal pain requires urgent medical attention), gallbladder disease (cholelithiasis and cholecystitis), and risk of dehydration potentially leading to acute kidney injury, particularly during treatment initiation

CT-388, a novel once-weekly dual GLP-1 and GIP receptor modulator, is safe, well-tolerated, and produces more than 8% weight loss in four weeks in overweight and obese adults

However, since valproate may interact with these or other concurrently administered AEDs as well as other drugs, periodic plasma concentration determinations of concomitant AEDs are recommended during the early course of therapy [seeDrug Interactions (7)]

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