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References and citations RESEARCH CITATIONS [1] Pickart L, Margolina A

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Mohn et al., 2008), probably due to the low affinity to methyl-binding proteins

Interestingly, this effect of male sex in hastening the onset of SP-MS and disability accrual has not been observed in more recent studies where a higher proportion of MS patients are receiving high-efficacy disease modifying therapies (30, 31), suggesting that the autoimmune inflammation may be a factor in the effect of male sex on progression

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free-drug occupancy method (albumin Kd 1.86 uM, free fraction 0.29%): Willard JCI Insight 2020