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Eligibility is based on BMI of 35 or more alone, or 27 or more plus other clinical criteria

In clinical trials, patients on Tirzepatide lost up to 21% of body weight, compared to around 15% on Semaglutide, making it an attractive option for patients seeking more aggressive weight loss

Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2

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In addition, mitochondria are also the primary producers of intracellular reactive oxygen species (ROS), most of which originate from the mitochondrial respiratory chain [55]

High-risk factors: Age over 60