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3) Recharging phase: The material is exposed to an exogenous high-concentration ion solution

Research from the Karolinska Institute in the 1950s demonstrated that glutathione concentrations dropped precipitously during oxidative stress events, confirming it was being consumed as a substrate rather than acting as a passive structural component

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PLoS Pathog 15:e1007581 Fortalezas S, Marques-da-Silva D, Gutierrez-Merino C (2018) Creatine protects against cytosolic calcium dysregulation, mitochondrial depolarization and increase of reactive oxygen species production in rotenone-induced cell death of cerebellar granule neurons

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2004, 10 (2 Suppl): S21-9