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Ultrastructural changes at the axonal level observed by electron microscopy in addition to early degenerative changes included focal edema, axonal debris accumulation, fluid pocket formation, neurofibril breakdown, and axon-associated glial edema, which in some cases showed signs of gliosis

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doi: 10.1159/000450619 108 KimuraI.InoueD.HiranoK.TsujimotoG