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The phase II clinical study, Calcium Up-regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID2), yielded no significant therapeutic effects

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Statistical differences were determined using either Students t test (2-tailed) or 2-way ANOVA followed by Tukeys post hoc test, as appropriate

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The cardiovascular evidence is the most solid: in the SELECT trial, people with obesity and established heart disease who added semaglutide cut their risk of cardiovascular death, a second stroke, or a second heart attack by about 20%