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At high concentrations, direct parasympathetic cardiac inhibition overrides the baroreceptor-mediated reflex response, resulting in bradycardia with prolonged RR intervals on ECG
doi: 10.3390/cells14141057 134 ZhaoYLiuHWangJZhangLChenYLiSet al
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More significant structural improvements reduced fine lines, improved firmness, better skin density typically become visible between weeks 8 and 12, with continued improvement through months 4 to 6 as collagen remodeling matures