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Always remember to check the final pH of your creation to ensure it falls within a skin-friendly range (typically 5.0-6.5) and add a broad-spectrum preservative to keep your product safe

The BBB prevents almost 98% of small molecule drugs and nearly all large-molecule therapeutics such as recombinant peptides, proteins, anti-sense agents, and genetic vectors, from reaching the brain [1]

The research is still early , but the mechanistic rationale is compelling

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Therefore, TDEE is typically higher than BMR

Understanding the full picture helps you make a more informed choice