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Table of Contents How Retatrutide Affects Heart Rate Retatrutide increases resting heart rate primarily through GLP-1 receptor-mediated chronotropic effects at the sinoatrial node, potentially amplified by its glucagon receptor agonism, which independently raises heart rate and cardiac contractility

Katz also stated that they are not recommending anyone stop using GLP-1 drugs or not use these drugs if theyre recommended by their doctor

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The US Food and Drug Administrations (FDA) independent advisory panel has recommended modifying the labeling of these two drugs to improve their cardiovascular safety profile

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