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The PI3K/Akt pathway also regulates the translocation of glucose transporter 4 (GLUT4) from intracellular vesicles to muscle and fat cell membranes, facilitating glucose uptake upon insulin stimulation

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10.1016/0014-5793(82)80455-9 57 CollisC.DaviesM.Rice-EvansC

I integrate these recommendations with patient constraintsincluding comorbidities, eGFR, GI tolerability, insurance coverage, and preferencesto ensure plans are feasible and evidence-based